That would actually be pretty cool. I remember a mission in Splinter Cell: Double Agent when you start off in prison and the whole thing breaks out in a riot/
So yeah I think that would be cool, but make it so a whole cell block is uninfected to make it believable. But these others wouldn't help you it would just be an all out riot with everyone panicking and stuff.
Another good thing would be if all the guards had abandoned the facility so there was just chaos
The four 'survivors' would be the four people in your cell.
I can actually see that as an awesome map!